1H-Indazole-3-carboxylic acid, 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester, endo-
8-methyl-8-azabicyclo[3.2.1]oct-3-yl 2H-indazole-3-carboxylate
CAS: 107007-94-3
Molecular Formula: C16H19N3O2
1H-Indazole-3-carboxylic acid, 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester, endo- - Names and Identifiers
| Name | 8-methyl-8-azabicyclo[3.2.1]oct-3-yl 2H-indazole-3-carboxylate |
| Synonyms | 8-methyl-8-azabicyclo[3.2.1]oct-3-yl 2H-indazole-3-carboxylate 8-methyl-8-aza-bicyclo[3.2.1]octan-3-yl 1H-indazole-3-carboxylate 8-Methyl-8-aza-bicyclo[3.2.1]octan-3-yl 1H-indazole-3-carboxylate 1H-Indazole-3-carboxylic acid, 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester, endo- |
| CAS | 107007-94-3 |
| InChI | InChI=1S/C16H19N3O2/c1-19-10-6-7-11(19)9-12(8-10)21-16(20)15-13-4-2-3-5-14(13)17-18-15/h2-5,10-12H,6-9H2,1H3,(H,17,18) |
1H-Indazole-3-carboxylic acid, 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester, endo- - Physico-chemical Properties
| Molecular Formula | C16H19N3O2 |
| Molar Mass | 285.34096 |
1H-Indazole-3-carboxylic acid, 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester, endo- - Introduction
8-methyl -8-aza-bicyclo [3.2.1] oct-3-yl 1H-indazole-3-carboxylic acid methyl ester, also known as MDOA, the following is a description of its properties, uses, preparation and safety information:
Nature:
-Appearance: colorless or yellowish crystal
-Molecular formula: C14H17N3O2
-Molecular weight: 255.31g/mol
-Melting point: about 42-45 ℃
-Boiling point: about 345-350 ℃
-Solubility: Soluble in ethanol, methanol and ether, insoluble in water.
Use:
MDOA is an organic compound commonly used in the field of chemical research. It is mainly used in the synthesis of other compounds, such as the preparation of pyrrole ring derivatives, which have important applications in medicine and material science.
Preparation Method:
The preparation of MDOA can be accomplished by a multi-step reaction. A common synthetic approach is from indazolones:
1. First, indazolone is reacted with aminoethanol to generate the corresponding primary amine compound.
2. Then, under acidic conditions, the primary amine is reacted with methanol to generate 8-methyl-8-aza-bicyclo [3.2.1] oct-3-amine methoxide.
3. Finally, 8-methyl-8-aza-bicyclo [3.2.1] oct-3-amine methoxide was reacted with carboxylic acid methyl ester to give 8-methyl-8-aza-bicyclo [3.2.1] oct-3-yl-1H-indazole-3-carboxylic acid methyl ester.
Safety Information:
The toxicity and dangers of MDOA have not been fully studied, so the relevant safety procedures of the chemical laboratory should be followed when handling. If the compound needs to be used, please ensure that it is carried out under suitable laboratory conditions and take necessary personal protective measures, such as wearing protective gloves, glasses and laboratory coats. During handling and storage, care should be taken to avoid contact with strong oxidants and high temperatures. When disposing of waste, follow the guidance of local codes and standards.
Nature:
-Appearance: colorless or yellowish crystal
-Molecular formula: C14H17N3O2
-Molecular weight: 255.31g/mol
-Melting point: about 42-45 ℃
-Boiling point: about 345-350 ℃
-Solubility: Soluble in ethanol, methanol and ether, insoluble in water.
Use:
MDOA is an organic compound commonly used in the field of chemical research. It is mainly used in the synthesis of other compounds, such as the preparation of pyrrole ring derivatives, which have important applications in medicine and material science.
Preparation Method:
The preparation of MDOA can be accomplished by a multi-step reaction. A common synthetic approach is from indazolones:
1. First, indazolone is reacted with aminoethanol to generate the corresponding primary amine compound.
2. Then, under acidic conditions, the primary amine is reacted with methanol to generate 8-methyl-8-aza-bicyclo [3.2.1] oct-3-amine methoxide.
3. Finally, 8-methyl-8-aza-bicyclo [3.2.1] oct-3-amine methoxide was reacted with carboxylic acid methyl ester to give 8-methyl-8-aza-bicyclo [3.2.1] oct-3-yl-1H-indazole-3-carboxylic acid methyl ester.
Safety Information:
The toxicity and dangers of MDOA have not been fully studied, so the relevant safety procedures of the chemical laboratory should be followed when handling. If the compound needs to be used, please ensure that it is carried out under suitable laboratory conditions and take necessary personal protective measures, such as wearing protective gloves, glasses and laboratory coats. During handling and storage, care should be taken to avoid contact with strong oxidants and high temperatures. When disposing of waste, follow the guidance of local codes and standards.
Last Update：2024-04-09 21:01:54
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